Studies On The Interactions Between Amphipathic Sodium Alginate Derivatives And Alkyl Polyglycoside

Combinations of macromolecule and surfactants are widely used in the development of various industries, such as oil, textile dyeing and finishing, cosmetics, food, and biopharmaceutical industries to take synergistic advantage of their unique properties, including the mechanical properties of polymers and the self-assembly behavior of surfactants. Sodium alginate is a kind of anionic linear polyelectrolyte with unique biological-chemical characteristics and good biocompatibility. Amphipathic sodium alginate derivatives obtained through hydrophobic modification have been applied in drug delivery and tissue engineering, but reports on the interaction of amphipathic sodium alginate derivatives and surfactant are few. In the present paper, cholesteryl grafted sodium alginate derivative (CSAD) and dodecanol grafted sodium alginate derivative (DGAD) were got through esterification reaction, and were reseached by fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance spectrometry (H’-NMR), differential scanning calorimetry (DSC) and thermogravimetric analysis (TG). These results demonstrate these grafted reactions were successful. Then the property of amphipathic sodium alginate derivatives were research by fluorescence spectroscopy and electron paramagnetic resonance (EPR), and they can form hydrophobic micro area because of the hydrophobic association within and among molecules. The surface behavior of OGP and CSAD in the gas-liquid interface were researched by surface tension. The result showes that the competitive adsorption of amphipathic sodium alginate derivatives and alkyl polyglycoside (APG) exists in the gas-liquid interface, and the action were intensified when0.1mol/L NaCl were added. The aggregation behavior of amphipathic sodium alginate derivatives and alkyl polyglycoside (APG) in solution were studied by fluorescence spectroscopy, dynamic light scattering (DLS), transmission electron microscopy (TEM) and electron paramagnetic resonance (EPR). The results show that the aggregation behavior of CSAD and decyl glucopyranoside (DGP) is homologous with the aggregation behavior between CSAD and octyl glucopyranoside (OGP). With the increasing of surfactants concentration, polymer-surfactant complexes, pearl-chain structure complexes and core-shell structure complexes were found stop by stop. However, the polymer-surfactant complexes have never appeared due to salt increase effect, when0.1mol/L NaCl were added. The aggregation behavior of DGAD and decyl glucopyranoside (DGP) is homologous with the model proposed by S.Biggs. However, the mixed micelle of DGAD and DGP has never appeared, when0.1mol/L NaCl were added.