Study On The Intensification Of The New Process Of Condensation Reaction With A Higee Reactor

Aldol condensation reaction is widely used in the chemical industry. However, condensation reaction is associated with some limitations such as complex reaction process and side reactions. From the reports of literature, the effect of mixing efficiency of materials on the quality of the product is significant. Higee technology, as one of the leading chemical process intensification technologies, can greatly strengthen mixing and mass transfer processes, reduce residence time and improve production efficiency. Therefore, this work took an example of the synthesis of a kind of hydroxy ketone compound (H) to study the influence of various process parameters on the conversion of raw materials, selectivity and yield of the target product in stirred tank reactor and higee composite reactor respectively. The structure of target product was characterized by GC-MS, IR and NMR. The enthalpy of the main reaction was also calculated. The main conclusions are as following:1. Experiments were carried out in an STR, the effects of reaction time (t), temperature (T), aldehydes/alcohol ratio (θ), aldehydes/alkali ratio (β), aldehydes/ketones ratio (e) and stirred rotation speed (n) on the conversion and yield were investigated.. Under the condition of aldehydes/ketones ratio 1:4, the best response conditions were as follows:aldehydes/alkali ratio was 1:0.15, aldehydes/alcohol ratio was 1:10, reaction temperature was 40℃, stirred rotation speed was 1000 rpm, reaction time was 25 min.2. Higee reactor was used to intensify the process of condensation reaction. Results revealed that under the conditions of aldehydes/ketones ratio 1:4, the best response conditions were as follows:aldehydes/alkali ratio was 1:0.10, aldehydes/alcohol ratio was 1:7.4, reaction temperature was 40℃, rotation speed was 2840 rpm, reaction time was 25 min.3. Higee composite reactor can accelerate the reaction rate. The reaction time was shortened and the amount of catalyst (33% reduction) and solvent (26% reduction) were reduced. The yield of target product was increased by 5%～10%.4. The macro-kinetics of the main reaction was discovered in the STR experiment. The results indicated that the reaction followed first order kinetics under the aforementioned operating conditions. The pre-exponential factor was 3.47×1010 L·mol-1 min-1 while the apparent activation energy was 60.99 kJ·mol-1. Thus, the macro-kinetics of the reaction was established as:d[P]/dt-k’[A]-3.47×1010 exp[-6.099×104/(RT)][C][OH-)[A]/[H2O]...