The Determinnation Of Non-steroidal Anti-inammatory Drugs And Dissolved Oxygen In Water

In recent years more and more attention has been paid toward the discharge, presence and potential effects of pharmaceutical in water. Thousands of tons of pharmaceutical are consumed yearly to treat or prevent illnesses, or to help people relieve the stress of modern life. The discharge of pharmaceuticals from pharmaceutical factories, hospitals and private household effluents produces a big burden on the environment, especially for water resources since the traditional wastewater treatment plants cannot eliminate them. These substances have several characteristics and longtime exposure to the active substances can cause potential risks for human health. We study nonsteroidal drugs and dissolved oxygen in drinking water as follows:1. A novel rapid analytical method for the determination of four non-steroidal anti-inflammatory drugs (NSAIDs)-nabumetone, ibuprofen, naproxen and diclofenac in tap water and drinks is presented. The method is based on ultrasound-assisted ionic liquid dispersive liquid-liquid microextraction (US-IL-DLLME) followed by ultra-high performance supercritical fluid chromatography (UHPSFC) coupled to a photo-diode array detector (PDA). The ionic liquid 1-octyl-3-methylimidazolium hexafluorophosphate ([C8MIM][PF6]) and methanol were used as the extraction and dispersion solvents for the DLLME procedure other than using a toxic chlorinated solvent. Plackett-Burman and Box-Behnken designs were applied as the experimental design strategies to screen and optimize the experimental variables which affected the extraction efficiency.4 NSAIDs were simultaneously separated and determined in 2.1 minutes. The optimized US-IL-DLLME-UHPSFC-PDA method showed good enrichment factors (126-132) and recoveries (81.37-107.47%) for the rapid extraction of nabumetone, ibuprofen, naproxen and diclofenac in tap water and drinks. The sensitivity of the proposed method has been successfully demonstrated to be reliable and cost-effective for the determination of NSIADs in water samples.2. This experiment has established the supercritical fluid chromatography coupled to quadrupole time of flight mass spectrometry method for analyzing pharmaceutical excipients porysorbate 80. In well optimized SFC-MS condition, porysorbate 80 was separated within 6 minutes. Through the mass spectrometry analysis, the effective ingredients was determined in polysorbate 80, including polyoxyethylene oleate, polyoxyethylene lino leate, poryoxyethylene sorbitan monooleate and polyoxyethylene isosorbide monooleate and inactive ingredients, including polyethylene grycol, polyoxyethylene sorbitan and poryoxyethylene isosorbide etc. In this experiment, every peak of polyethylene glycol reached the baseline separation, so that the quality of polysorbate 80 can be judged through the quantitative analysis of polyethylene glycol.3. This experiment successful synthesized the fluorescence indicator [Ru (dphphen)3](ClO4)2,using polymer embedded it, and made a sensing film. After setting up a dissolved oxygen sensor device, the performance performance of the sensing membrane was tested. This sensing membrane has small size, high sensitivity, good repeatability and stability, without consuming oxygen, can be used for continuous measurement of gas, liquid samples.