Nanocomposites For Bone Reparation Containing Bioactive Carbon Nanofibers

With the development of social economy, high-energy damage such as traffic injury, falling hurt is now increasing, as well as comminuted fracture. To improve the fracture healing and make a good functional recovery, bone repair devices are needed to be used to improve the reduction and fixation. Orthopedic devices made of traditional metal materials and the single polymer orthopedic devices have their innate shortages. The research and development of biocompatible polymer matrix composite bone reparation and medical care materials with high strength, moderate modulus and low stress shelter effect become a hot research topic in the field of bone implant material.In this research, we use chopped calcium phosphate nanoparticles@ carbon nanofibers to enhance medical acrylic resin, and give the materials biological functions. This research developed a new type of nano biomaterial using in bon repairment and medical care products.Firstly, combining the sol-gel method, electrostatic spinning technology and situ sintering technique, for the preparation of calcium phosphate nanoparticles adhered carbon nanofibers. By controlling the conditions of the sol-gel method, electrostatic spinning technology and situ sintering technique, this research successfully developed a type of calcium phosphate nanoparticles@ carbon nanofibers with concentrated diameter distribution and homogeneously dispersed nanoparticles. The main composition of calcium phosphate nanoparticles are P-TCP and HA, load up to 12 wt%.More importantly, due to its main load nanoparticles are within the fiber, it has a high retention of nanoparticles under the condition of the physical processing. After 40 minutes of 500W high power ultrasound sonication, it still can maintain 80% of the nanoparticles. It’s a ideal choice of short biological activated carbon nano fiber reinforced filler.Using high power ultrasonic shear technology, this research successfully cut CNF/CaP to be discrete chopped fiber, its length distribution focus on 3μm. The fiber length distribution can be controlled by adjusting the ultrasonic parameters. This type of short carbon nano fiber can be used to reinforce acrylic resin to obtain new type of biological nano-composite. CNF/CaP is the enhancement component, and can provide a certain amount of biological activity and bone induction. In this research, certain type of composite material developed by the bending strength of up to 160 MPa, bending modulus can reach 6 GPa, similar to the mechanical properties of human cortical bone, can satisfy the requirement of as bone plate material.To sum up, chopped calcium phosphate nanoparticles @ carbon nanofibers and acrylic resin composite materials have moderate mechanical properties, good biocompatibility, strong applicability, is expected to become a new generation choice of biological nano composite material using in bone repair devices.