The Preparation And Performance Of Fiber For Drug Controlled Release Based On Fibroin

Drug delivery system is a kind of pharmaceutical preparations delivering the drug to the patient in expected way and controlled medicated speed. It can improve therapeutic efficiency, reduce toxicity, minimize dosing frequency and deliver drug in a stable speed for a long period. Recently, many drug delivery systems have been prepared such as tablet, capsule, microspheres etc. Drug controlled delivery system based on micro-fiber has been widely investigated due to its large surface area, excellent second preparation, simple preparation methods. Additionally, it is easier to control the microstructure of micro-fiber drug delivery system by changing spinning method and parameters.In this paper,micro-fiber drug delivery system based on fibroin was prepared by coaxial wet spinning. The microstructure and performance of coaxial fiber were studied by linear density test, scanning electron microscopy(SEM), mechanical test and water absorption performance test. The results showed that the proper coagulation bath temperature to prepare fiber with uniform structure and good performance was about 20℃, the volume of ethyl alcohol and water in the coagulation bath was around 5:5, the appropriate mass fraction of cortex solution and core solution were 20% and 30% respectively, while the suitable take-up speed was 1.08m/min.With acetylsalicylic acid as model drug, micro-fiber drug delivery system based on fibroin was prepared. Effect of the percentage of fibroin in cortex solution, the content of drug-loaded in core layer, the spinning speed on the morphology and structure of coaxial drug-loaded fiber were studied. The results showed that the drug release behavior was controlled by changing the percentages of fibroin in cortex solution, the content of drug-loaded in core layer and the spinning speed.Melt spinning method was used to prepare micro-fiber drug delivery system based on fibroin and PCL. SEM images indicated that when there were no fibroin microparticles, the fiber was formed with dense structure. Whereas, with the increase of percents of fibroin microparticles from 2% to 10%, the fiber structure became loose gradually with more and more micropores in cross section. Drug release test implied that with the percent of fibroin microparticles increasing from 0% to 10%, the drug release amount within 2h was decreased from 45% to 25%. It proved that the burst effect was weakened by the addition of fibroin microparticles. The fiber was prepared with good secondary process performance by the loom for weaving sample in the lab.Therefore, micro-fiber drug delivery system based on fibroin was prepared to control the drug delivery. In future, it will have wide applications in functional gauze and artificial organ.