Study On The Synthesis Of Estrone Derivatives Of Steroid Hormone Drugs

Oestrogen have been widly used in treating different kinds of wemen's diseases and as important parts of contraceptives because of their characteristic physiologically activities . Today, most of oestrogen are made from nature steroid resources by chemical and biological processes.On the base of literatures, a reasonable route has been given out in this paper. We have synthesized three estrone derivatives in this way, which includes estrone 3-cyclopentyl ether, 1,3,5,16-estratetraene-3,17 P-diol 17-acetate 3-cyclopentyl ether and 16a,17a -epoxy- 1,3,5-estratriene-3,17 P -diol 17-acetate 3-cyclopentyl ether. The effects of reactive molar ratio, temperature, time and catalyzater on the jield of product in each step were studied and the optimal reactive conditions have been found . Each product have been indentified by IR, 1H NMR, 13C NMR and MS spectra.In addition, we tried to treat ,3,5,16-estratetraene-3,17 3-diol 17-acetate 3-cyclopentyl ether with alkali 30% hydrogen peroxide and found out it was hydrolysised instead of being epoxidized in the end.