1,2 - Cyclohexanediol Synthesis Of The New Technology Research,

The study of New Technology study of Synthesizing 1,2-cyclohexanediol" is one of subjects funded by Henan Outstanding Person Foundation. Aiming at demand of national economy and linking the actual condition of domestic refinery chemical , a routine with cyclohexene as main raw material was developed in the thesis.As a kind of impotant fine chemical product , O-dihydroxybenzene has a prosperous future in the field of medicine,pesticide,spice and fine organic synthesis. To prepare O-dihydroxybenzene with cyclohexene , trans-1.2- cyclohexanediol is a very important organic intermediate. Firstly, there is quite a few reports on the synthetic technology of trans- 1,2-cyclohexanediol in the country and the reports are even less about cyclohexene abroad. So thie thesis developed and obtained the new technology routine which adopts the original position method to synthesize 1,2-cyclohexanediol directly.At first, on the base of the formula structure of cyclohexene and correlative organic synthesis theory, we draw up the experimental scheme of the synthesis of trans-1.2-cyclohexanediol,. Then with the orthogonal design method and single-factor-experiment, analyzing with GC, the key factors affecting this complicate reaction were determined.,. Furthurmore we refocused the influence of temperature, acetic acid, hydrogen peroxide, the ratio of acetic acid and acetic anhydride. The ideal synthetic process conditions are acquired.On these bases, by means of the technology of artificial neural network, the 5-3-2-1 model of artificial neural network which is used to predict the optimal operation condition of the synthesis of cyclohexanediol was construced. With this model the error of experimental value and calculation value is only 1.78523% when it is fully optimized , it is made sure that this model is credible, so we could obtain the optimal synthesis reaction condition as follows:Taking cyclohexene O.lmol as base,temperature: 40~45℃;reaction time : >=90min;resting time after reaction: 24h;adding acetic acid : 1.2moladding hydrogen peroxide: 0.13molextraction times: 8In addition, we had a ultimate forecast, and its result was very close to the result of opitimal experiment.In this thesis, on the surface percentage yield is only 75 percent, but the unused acetic acid and ethyl acetate can be recycled. In addition, in this thesis the most pivotal is the selectivity, and not the percentage yield. The selectivity in this reaction is up to 96 percent calculated with unitary method.We studied the kinetics of the synthetic reaction of trans-1.2-cyclohexanediol and obtained the kinetic equation as folloes:Through the equation ,the best reaction time is obtained.This reaction will by-produce a lot of waste acid and ethyl acetate, this thesis also researched into their recycling problem.There are two outstanding advantages in this thesis. Firstly, the selectivity is very high, and little byproduct is abtained; Secondly, all materials can be circulatively used.In a word, in the thesis the optical processs condition of synthetic reaction of trans-1.2-cyclohexanediol was determined and the kinetic equation of the reaction was established. All these provide some design parameters and theoretical bases for the project design and Industrializing producing.