Juglone And Its Derivatives

This thesis reviewed the medical activity of Juglone, a natural product, and summarized the previous synthesis methods of Juglone, and a detailed evaluation of them provided some helpful comments for the subsequent synthetic researches of Juglone.In this paper, a new preparative method of Juglone was attempted through a series of reactions of nitration , oxidation, reduction, diazitization and hydrolysis starting from the commercially available naphthene. All of the obtained compounds were characterized by IR and 1H-NMR.The structure of the Juglone is similar with the standard data.After having acquired the Juglone, the author of this thesis attempted to prepare a derivative of Juglone: 5-hydroxy-8-methyl-1,4-naphthoquinone, however, no confirmative conclusions were obtained.