Hydrochloride Buflomedil Synthesis Process

This research work have studied the preparation process of buflomedil hydrochloride .The experimental plan is determined by analyzing various process both from home and abroad: using trinitrotoluene as raw material, through oxidation, catalytic hydrogenation , hydrolyzing in turn ,the yield of phloroglucinol is 60%. γ-Chlorobutanoyl chloride is synthesized by u-sing γ-butyrolactone as raw material and zinc chloride as cafalyst, its yield can reach 88.4%.Through etherification ,the 1,3,5-trimethoxybenzen is synthesized with its yield 89%.using 1,3,5-trimethoxybenzen and -Chlorobulanoyl chloride as raw material , bullomedil hydrochloride is synthesized through Friedel-Crafts reaction ,N-hydrocarbylation ,salini-zation with its yield 64.5%.Furthcrmore ,its structure is determined by UV,IR,1HNMR and its optimum experimental conditions are also determined.