.10 H-[1,3] Dioxane [4,5-g] Indeno [1,2-b] Quinoline Derivatives Synthesis

In this paper, the progress of Friedlander condensation reaction in synthesizing quinoline's compounds is summarized. According to a lot of material, we design the synthesis of 10H-[1,3] dioxol [4,5-g] indeno [1,2-b] quinoline's derivatives. And the five target compounds have been synthesized by Friedlander condensation reaction.At the room temperature, 6-nitropiperonal (2) has been prepared from piperonal (1) in the presence of acetic anhydride with nitric acid. Added ferrous sulfate and ammonia, 6-nitropiperonal was reduced to 6-amonopiperonal (3) in boiling. With the sodium ethoxide catalyzed, the compounds (3) condensed with five 1-indanone's derivatives (4a) ~ (4e) respectively, and yielded five new compounds (5a) ~ (5e). The new compounds are all 10H-[1,3] dioxol [4,5-g] indeno [1,2-b] quinoline's derivatives. The construction of compounds (5a) ~ (5e) were confirmed by IR, MS, 1H NMR and Elemental Analysis.In this paper, the reaction conditions of Friedlander condensation, such as solvent, catalyst, reaction temperature and time were discussed. The synthesis is useful to produce and extend new medicine production in the industry. It offers the basis of studying and producing new medicine.