Synthesis And Properties Of S-naproxen Imprinted Polymer Materials

Molecularly imprinted polymers were prepared using S-naproxen as a template molecule. The effect of type of functional and cross-linking monomers, as well as degree of cross-linking on the binding capacity of polymers, has been studied by equilibrium binding assay, Scatchard model and surface area and pore analysis. The results indicate polymers synthesized by acrylamide yielded the highest, polymers synthesized by methacrylic acid or N-vinylpyrrolidone yielded lower. And divinylbenzene is a better choice as the cross-linker compared with ethylene glycol dimethacrylate, yielding polymers with higher analyte binding. Binding isotherms revealed binding capacity of polymers decrease with the degree of cross-linking. Intramolecular hydrogen bond between template molecule and functional monomers was studied by UV spectroscopy, which provide an explanation for the difference of binding capacity of polymers prepared by different functional monomers. Experiments of selectivity show that recognition properties of polymers increase with the degree of cross-linking. Molecularly imprinted polymers of S-naproxen were prepared to use as chiral stationary phases in thin-layer chromatography (TLC), and the results reveal that TLC based on MIP could succeed the direct separation of enantiomer of naproxen as a method of separation , R=1.67.