Sulfate Synthesis Process For M Star

An improved synthetic process for Etimicin Sulfate, which was developed independently and was the first antibiotic of new medicine of category I in China, was discussed. The process for converting gentamicin C1a, the starting material, to 1-N-ethylgentamicin C1a, comprised the step of selective blocking of some amino groups utilizing transition metal salt complexes, and the new step of blocking of hydroxyl groups utilizing the silylation process which was not reported by the invention patent, and the step of N-ethylation of 1-N amino group through condensation-reduction reaction. Finally, Etimicin Sulfate bulk medicine, which reaches the State Drug Standard, was obtained by salification with sulfuric acid. The conditions of the said reaction were also improved. The overall yield of the product was 37.3%. There is an obvious improvement compared with the yield reported by the patent, and very good result of this process in the pilot manufacture was also obtained. Therefore, this improved process shows considerable value in commercial manufacture. The results and reaction mechanism have been rudimentarily analyzed and discussed.