Tetraaza The Aromatics Tetraaza Cyclophanes Synthetic Research

Supramolecular chemistry is a cross subject in chemistry, which is contact with material sciences and information sciences, life sciences. It is in the highest flight of chemistry. In organic chemistry and supramolecular chemistry, one of the explosive studies are the design of artificial organic compound which has molecular recognition properties, synthesis and application. The basic characteristic in supramolecular chemistry comes into being the host-guest complex on the basic of molecular recognition. As the host compounds, for example crown ethers, cyclodextrins, calixarenes, cyclophanes which take out interesting achievements in a lot of studies.Calixarene is a ring compound with unique conformational and cavity structures. A series of new calixarenes which have fine-tuned cavities are synthesized by a fragment coupling approach. A number of aza-bridged calix[n]arene[2]triazines have been synthesized through cheap raw material, an unusually high yielding and efficiency in gentle condition. The aza-bridged calix[n]-arene[2]triazines will be obtained wild application in the studies of molecular recognition, sensing technology, supramolecular assembly, mimic enzyme and catalysis, though being easy to modification and reconstruction in function. In the part 1, the aza-bridged calix[4]arene[2]triazines and aza-bridged calix[2]arene[2]triazines were synthesized and characterized by MS, IR and ~1HNMR.Tetraazaparacyclophane is a kind of important compound in cyclophane, and a kind of compound which can act as host in host-guest chemistry. As artificial enzymes, using hydrophobic cavities, they can capture different organic molecule to form the host-guest system, based the different of the ring site, size and interaction. By changing the ring site and size or modifying the cyclophane with the reaction, improving the water solubility of compound , we can design the novel active center with coordinated inclusion and multirecongnition to get the special host, which would form the supramolecular system with the guest and actualize the molecular recognition and the simulation of enzyme function. In the part 2, the approach with modifying 1,6,20,25-tetraaza[6,1,6,l]paracyclophane(CP44) has been ameliorated. Above all, we modified p,p'-diamino-diphenyl-methance and closed the ring to get 1,6,20,25-tetracarbethoxy methyl-1,6,20,25-tetraaza[6,1,6,1]paracyclophane.