Venlafaxine Hydrochloride Synthesis And Chiral Separation Method

The present thesis has chosen anti-depressant medicine Venlafaxine as the research substance, which has an asymmetrical center in the molecular. A series of chiral compounds had been chosen and designed to resolve the racemic Venlafaxine. And discussed and researched the synthetic method and resolutive method of the related compounds.Firstly, according to the principle of Grignard reaction,four kinds of chiral diols have been synthesized by the reaction between inexpensive natural products, L- lactic acid ethyl ester, and the magnesian compounds. The chemical names of the four kinds respectively are (S)-1,1-diphenylpropane-1,2-diol, (S)-1,1- dip- tolylpropane-1,2-diol, (S)-1,1- bis(4-methoxyphenyl) propane- 1,2- diol and (S)-2- benzyl-1-phenylbutane-2,3-diol. And the characteristic of them has been researched.Secondly, on the basis of literature review,a synthetic method in the laboratory has been decided. Through the nucleophilic addition reaction, the catalytic reduction reaction and the amine methylation reaction Venlafaxine is obtained.Finally the preliminary research has been conducted on the resolution of venlafaxine by the chiral diols and the diols' characteristic as well, however,the anticipated goal has not been achieved.