Synthesis, Structure Characterization And Properties Of The Of Organotin Acylhydrazone Acetate Study

Organotin complexes have been used extensively as catalysts, stabilizers, biocides, anti-fouling agents and wood preservatives. In recent years, the investigations on the structure mode and biological activities, especially anti-tumor activity, of organotin complexes have become the focus on organometallic chemistry. In this thesis, more than 10 organotin carboxylates were synthesized by the reactions of triphenyltin hydroxide, trihexamethylenetin hydroxide, bibutyltin oxide with various 2-(ethane acylhydrazone) acetic acid and 2-( benzoyl acylhydrazone) acetic acid. These organotin carboxylates were characterized by elemental analysis, IR, NMR spectra, and 6 single crystal structures of the typical organotin compounds were determined, and their variations on structure and property were also discussed. The thesis contains the following works.6 organotin carboxylates with the 2-(ethane acylhydrazone) acetic ester and 2-( benzoyl acylhydrazone) acetic ester were synthesized by the reactions of triphenyltin hydroxide, trihexamethylenetin hydroxide, bibutyltin oxide with various acylhydrazone acetic acid which were synthesized from the acylhydrazine prepared before. The structures of six carboxylates such as C₆H₅CONHN=CHCOOSnCy₃ (7), (C₆H₅CONHN=CHCOOSnBu₂) 2O (8), (CONHN=CHCOOSnCy₃)₂ (10) , C₆H₅OCH₂CONHN=CHCOOSnPh₃ (11) , C₆H₅(OSnCy₃)CO NHN=CHCOO- SnCy₃(12),NH₂SCNHN=CHCOOSnPh₃(13) were determined.The inhibitory effects on HeLa (cervix cancer), the bacteriostatic power on Escherichia coli and the catalytic power to acyloin condensation and to ester exchange reaction of several typical organotin carboxylates were measured and obtained good resuits.The data of the first experiment indicated that theses compounds have antitumour activities;and the data of the third experiment showed that some of these organotin carboxylates have catalytic power and high selectivity to acyloin condensation and to ester exchange reaction.