The Synthesis Of The Triazole Antifungal Agents And Their Biological Activity Was Detected

Fluconazole were synthesized from 1,3-difluorobenzene in several steps on the basis of three dimensional structure of P450 cytochrome 14α-sterol demethylase (CYP51).At the same time have a try to join the carbohydrates to the medicine group according to the antifungal mechanism and structure-activity relationship of triazolanol compounds. All intermediates and title compounds were ascertained by means of ~1HNMR and IR.And their antifungal activities were also evaluated Choosing Candida albicans and Aspergillus fumigatus. Use the method of round filter paper to observe the shape of the compound's effect on fungal. Use the methods of weight to observe the fungal growth after the compounds joining with the fungal. With the two methods we can get the results in some degree.In chemistry have synthesized fluconazole, and have a try to join the carbohydrates to triazole antifungal medicine group, at last failed and analyzed the reasons.In biology have a biological test of fluconazole and an intermediate. The results showed that the two compounds exhibited antifungal activities against the two common pathogenic fungi to some extent.Compared with the intermediate, Fluconazole showed that it had a better antifungal result.Conclusion: the triazole compounds showed good antifungal activity, and it is a good choice for further study.