Fluoroalkyl Azide Reaction

My Master dissertation is focused on the study of synthesis and reactions of fluoroalkyl azides RFCH₂N₃, and consists of three parts of contents.The first part of dissertation focused on the synthesis of the fluoroalkyl azides starting from 2,2,2-trifluoro-ethanol and 2,2,3,3-tetrafluoro-propan-1-ol.The reaction of fluoroalkyl azides and related fluorine containing compounds were presented in the second part. It contained the reaction of 1,3-dipolar cycloaddition of fluoroakyl azides and the reaction of the fluorine containing aza-Wittig reagents N-fluoroalkylimino phosphoranes derived from fluoroakyl azides. The application of 1, 3-dipolar cycloaddition of fluoroakyl azides in the synthesis of fluoroalkyltriazoline and fluoroalkylpyrazolines was also discussed in this part.The third part related to the synthesis of 1H-prano [3,4-d] [1,2,3]triazol-4-ones. Which were synthesized from 5-alkyne-1H- [1,2,3] triazole-4-carboxylic acid via Ag₂CO₃-catalyzed intramolecular cyclization. And their physiological activities were tested.