The Synthesis Of Chiral Binaphthyl Derivatives, Immobilization, And Catalytic Hydrogenation

Asymmetric Catalysis is the forefront of the field of organic chemistry and the direction of development. In recent years, the search for high enantioselectivity and high catalytic activity of chiral ligands, by homogeneous catalyst load solution of the hands of expensive metal catalyst separation and recycling of green-oriented and practical use of the asymmetric catalysis is the latest Asymmetric Catalysis on hot issues. In this paper, using a C2-hand of Binaphthol synthesized a series of three and 3,3 '-substituted chiral Binaphthol derivatives, and applied to four allyltin p Formaldehyde Allylation of catalytic reaction was better catalytic effect. At the same time the use of a controllable mesoporous Nanoinorganics SBA-15 for the carrier, will hand of the two single-naphthol phosphorus ligand with a metal ruthenium coordination, supported at the same time, achieve a homogeneous catalyst load. Discussion of such a mesoporous structure of supported catalysts in the hydrogenation of aromatic ketones catalytic properties of the catalytic reaction. Major research are as follows:First,1,3 and 3,3 '-substituted chiral Binaphthol derivatives of benzene and formaldehyde in the reaction of allyl the application. From the hands of Binaphthol departure, after multi-step reaction of a series of 3,3 '-substituted chiral Binaphthol derivatives; discussed in the four allyltin allyl of benzaldehyde Reaction in the application of results of the study found that: In addition to three c conversion rate is 73.2% and the remaining conversion rate of more than 90%, 3 b is> 99%, compared with no catalyst, the conversion rate greatly improved, compared with BINOL, 3 b , 3c also has a more pronounced effect.Second, mesoporous materials SBA-15 load of the hands of the two phenolic naphthalene single phosphorus ligand and metal catalysts in the synthesis of aromatic ketones asymmetric hydrogenation reaction in the application. From the hands of Binaphthol departure, after a multi-step reaction of a mesoporous structure of the SBA-15 load chiral ruthenium metal catalyst. Replace aromatic ketones inspected the asymmetric hydrogenation, which supported metal catalysts aromatic ketones in the asymmetric hydrogenation catalysts demonstrated high catalytic activity.