Carbon Nanotube Based Magnetic Composites And Modified

Magnetic targeted drug carrier is the most fundamental sustentation for Magnetic Targeted Drugs Delivery System (MTDS). In this work the technology of preparing Fe₃O₄/CNTs magnetic composite nanoparticles by solvent-thermal reaction was studied, taken ethylene glycol as the medium. It is made a system discussing about the methods and reaction mechanism of purification and surface functionalization of carbon nauotubes (CNTs), and which influenced the preparation of Fe₃O₄/CNTs composite particles. This paper also studied the influence of reaction condition, namely components like polyethylene glycol (PEG), acid sodium (NaAc), and etc. and temperature in reaction system, on the homogeneity, stability, phase and crystal size of Fe₃O₄ nano-particles located on CNTs surface. The Fe₃O₄/CNTs Particles were characterized by XRD,FT-IR,TEM,VSM.The results showed that, magnetic material, around the surface of Fe₃O₄/CNTs Magnetic Composite Nanoparticle prepared by the experimental methods which are mentioned in this paper, coated homogeneously, sufficiently with good magnetic properties, and met the requirements of the magnetic targeted therapy carrier towards every property of particles. Besides, this research also made surface modification of prepared composite particles by using SiO₂, and prepared SiO₂/Fe₃O₄/CNTs composite particles. The results showed that: around the SiO₂/Fe₃O₄/CNTs composite particle surface, the thickness of the amorphous SiO₂ shell was homogenous and moderate; compared with the Fe₃O₄/CNTs particles, the saturation intensity of SiO₂/Fe₃O₄/CNTs particles decreased relatively small; Fe₃O₄ in composite particles got sound protection, and improved the stability of particles. Meanwhile, the newly-added SiO₂ shell strengthened the drugs absorb and slowly-releasing effect of composite particles. The efficacy listed above is tested by drug-loaded release experiment of composite particles towards Aspirin.