Labeling Technique Based On Nano-magnetic Materials For Magnetic Targeted Therapy

A biocompatible magnetic nanocomposite particle for magnetic targeting radiotherapy was systematically synthesized in this paper. This research contains the preparation of hydrophilic and hydrophobic Fe3O4 nanoparticles using polyol process, the coating of hydrophilic Fe3O4 nanoparticles with SiO2 and the amino functionalization of Fe3O4/SiO2 composite particles, the highly efficient and stable covalent binding of both [188Re(H2O)3(CO)3]+and folic acid to the surface of the iron oxide nanoparticles for radiopharmaceutical application, the synthesis of particles with dual magnetic and fluorescent capabilities. This work could serve as a foundation for the application of functional magnetic nanocomposite particles for radiopharmaceutical application and fluorescence tracer. The main content were described as follows:Firstly, the monodispersed and superparamagnetic nanoparticles were synthesized with a polyol method, Characterized the product with XRD, TEM, FTIR, VSM. The results showed that the particles had a narrow size distribution about 8-12nm and good crystalline. Magnetic property tests showed that the saturation magnetization reached 67.1emu-g-1and 56.9emu-g-1, demonstrated the particles had a good magnetic responsiveness and superparamagnetism.Secondly, magnetic Fe3O4/Sio2 core-shell nanoparticles were prepared by a sol-gel reaction using TEOS as a precursor. The surface of Fe3O4/SiO2 magnetic nanocomposite particles were functionalized byλ-aminopropyl triethoxysilane. Then radiopharmaceutical Fe3O4/SiO2 particles were synthesized by bonding of the amine-functionalized nanoparticles with folic acid molecules. The structures, compositions and magnetic properties of Fe3O4/ SiO2 composite particles were characterized by XRD, FTIR, TEM, VSM. The HPLC and Raman results show that folic acid (FA) molecules chelated with [188Re(H2O)3(CO)3]+were successesed conjugated on the surface of Fe3O4/SiO2 particles.Finally,Fe3O4/ZnS core-shell nanoparticles were prepared by high-boiling solvent process and sol-gel methord, hydrophobic Fe3O4 nanoparticles were coated with ZnS using ZnCl2 and Na2S. This procedure combined magnetism with fluorescence. The fluorescence labeled nano iron oxides used as the core to achieve precisely targeted positioning.