Part Of Superparamagnetic Nano-materials Synthesis And Biological Applications, Based On Mri

Magnetic resonance imaging (MRI) has been one of the most powerful medical diagnostic tools due to its noninvasive nature and multidimensional tomographic capabilities coupled with high spatial resolution. Recently, the application of magnetic nanoparticles has been extended into the biomedical system such as MRI, biological separation and magnetic hyperthermia therapy. Among them, MRI is one of the most rapidly developing research areas. Monodispersed amphiphobic FePt nanoparticles with the diameter of about 3-10 nm were synthesized by high temperature pyrolysis of iron(III) acetylacetonate and platinum(II) acetylacetonate and add little oleic acid as surfactant. FePt nanoparticles are well dispersed in water and many organic solvents. They provide a superparamagnetic property with the saturation magnetization (Ms) of about 25 emu/g. The transverse relaxivity (r2) is 122.6 Fe mM-1 s-1 in aqueous solutions.and it has good effect in HeLa cells.This experiment also uses high-temperature pyrolysis method to synthesis oil-soluble metal-oxide magnetic nanoparticles firstly, and then hydrazine hydrate deamination of protection methods prepared monodisperse, amino-functionalized, water-soluble iron oxide nanoparticles. Striking feature of this method is using of olelamine and phenyl ether as solvent, high-temperature pyrolysis of 6-(1,3-dioxo Isoindoline-2-yl) hexanoic acid precursor of iron together, the surface ligand is of 6-(1,3-dioxo Isoindoline-2-yl) hexanoic acid of the oil-soluble magnetic nanoparticles, and then hydrazine hydrate off of 6-(1,3-dioxo Isoindoline-2-yl) hexanoic acid on phthalic anhydride, Skillfully oil-soluble nano-particles into amino-functionalized and water-soluble iron oxide nanoparticles . And thses water-soluble nanoparticles in magnetic resonance imaging-based detection of bacteria also showed the role of a good result.