The Treatment Of Depression Instrument Developed And Applied Research

Objective:The disease of depression is a frequent disease harmful to our health with 6.1%-9.5% lifetime prevalence not only affecting working efficiency and living standard of patients but also causing death, bringing heavy burden to our society.The present study is focused on advanced developing aiti-depression instrument based on the biological effect of electronic wave, and investigateing antidepressant-like effect and the security of different frequency of the aiti-depression instrument, and its mechanism.Method:The electronic-based anit-depression instrument was designed with embed system of ARM9 CMOS chips combined with LINUX operative system.30 mice were divided into three groups including high frequency group, low frequency group, control group and model group. The high frequency group and the low frequency group received rTMS for 5d and the control group and model group were not treated with rTMS. The open field test and force swimming test were performed to observe the security and antidepressant effect of rTMS, respectively, and the expression of mRNA of adrenalin receptors in hippocampi was detected with RT-PCR.Results:The anti-depression instrument demonstates safety and stability. Open field test displayed no significant difference in the high/low frequency group and control group. Force swimming test showed the latency of low frequency group increased while the immobility reduced compared with model group, the expression of mRNA of adrenalin receptors in hippocampi in low frequency group was similarly to that in control group, but lower than that in high frequency group.Conclusion:rTMS within certain frequency and intensity is safe. Low frequency not high rTMS has antidepressant-like effect.