Correlation Of Transforming Growth Factor-β1 Gene -509c/t Polymorphism And Genetic Susceptibility To Non Small Cell Lung Cancer In Chinese Population

Objective: To investigate the possible association between transforming growth factor-beta1(TGF-β1) -509C/T polymorphism and susceptibility to non-small cell lung cancer (NSCLC) in Chinese population.Methods: We investigated the associations of TGF-β1 -509C/T polymorphism with the susceptibility and clinical tumor characteristics of 210 NSCLC cases and 208 controls matched with sex and age. The polymorphism were detemined by using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Logistic regression analysis was employed to assess the associations between genotypes and the risk of lung cancer, adjusting for multiple confounding factors.Results: The TGF-β1 -509C/T T allele had a significantly increased risk for NSCLC (p = 0.001;Odds ratio: 1.617; 95% Confidence interval: 1.210-2.161 ) as compared with the C allele. The T-allele carries(CT or TT genotypes)had a significantly increased risk for NSCLC(p=0.007,OR=2.297,95%CI:1.250-4.219)when compared with CC genotype. People who smoked heavily had a increased lung cancer risk(p=0.021,OR=1.783,95%CI:1.089-2.919).Conclusions:Our study suggested that the T allele of TGF-β1 -509C/T was associated with the increased risk for NSCLC and the TGF-β1 -509C/T polymorphism may be a important marker for susceptibility to NSCLC in Chinese population. The precise mechan- isms of the polymorphismon the differing status in NSCLC should be elucidated in further studies.