The Impact Of Intensive Insulin Therapy And Antioxidant Treatment On The Acute Insulin Release Function In Newly Diagnosed Type 2 Diabetic Patients

Objective: To explore the impacts of short-term intensive insulin therapy and antioxidant treatment by alpha-lipoic acid on the acute insulin release in newly diagnosed type 2 diabetic patients.Methods: Twenty-eight newly diagnosed type 2 diabetic patients were randomly divided into observing groups and controlling groups. The observing group was added alpha-lipoic acid from the second week of intensive insulin therapy, while the controlling groups for two weeks of intensive insulin therapy .Three intravenous glucose tolerance tests (IVGTT) were performed before and after the first and second week by such treatments to measure the levels of 0 minutes blood glucose and 0min, 2min, 4min and 6min blood insulin level, the increase of acute insulin release△INS (AIR2,4,6) ,beta-cell function index(HOMA-β) and insulin resistance index (HOMA-IR) were calculated.Results: 1. Intensive insulin combined with antioxidant treatment byα-lipoic acid for one week could significantly improve the level of acute insulin release;However there are not significantly difference between it and only treating by intensive insulin for two weeks. 2. Insulin resistance is not significantly improved in both groups. Conclusion: Intensive insulin therapy and combined with antioxidant treatment byα-lipoic acid for one week could significantly improve the level of acute insulinrelease; Combined withα-lipoic acid don,t have additional effects compared with treating by insulin alone;Neither of the two methods can improve insulin resistance.