Study On Anticarcinogenic Bioactivity Of Oligosaccharide Selenite

Oligosaccharide show a variety of biological activities, such as antitumor, and they can improve the body's antioxidation, and so on. So we pay more and more attention on oligosaccharide. Recently, many polysaccharide sulfates have been researched as antitumor drugs, while oligosaccharide selenite is several mentioned.Oligosaccharide selenite was prepared and studied. We synthesized by changing reaction condition and improving synthesis technology. Two selenite compounds are stabilized, hydrosoluble and high Se content. And their structure was determined by IR spectrometer and UV spectrometer.With regard to their biological activities, in Ames Test, oligosaccharide selenite could evidently inhibit the reverse mutation on Salmonella thphimurium strains TA98 with S9 mix. We also studied their effects on HeLa cell. The results show that both bucrose selenite and raffinose selenite are better than sodium selenite in inhibition. In addition, we also have a living animal experiment to oligosaccharide selenite, such as tumor inhibition, life extending, animal nutrition, acute- toxicity.