Clinical Analysis Of Pregnancy Complicated With Hyperthyroidism

Objective: To investigate whether the treatment in pregestational and gestational period can reduce the pregnant complications and the rate of fetal loss and improve the maternal and fetal outcomes in women with hyperthyroidism (Graves disease) before pregnancy and during pregnancy. Methods: A retrospective study was conducted on 104 healthy pregnant women and pregnant women with hyperthyroidism in our hospital from 2001 to 2009. The therapy in pregestation and gestation period and the rate of fetal loss were analyzed. All women were divided into three groups: the first group (healthy pregnant women) denied any history of hyperthyroidism; the second group(well treated women) with hyperthyroidism history before pregnancy or during pregnancy who had received antithyroids during pregestational and gestational period and resulted euthyroidism without recurrence; the third group (unwell treated cases): who did not receive,presented late to the clinics with severe conditions and resulted thyroid dysfunction. Results: (1) Pregnancy age, duration and gestational age of three groups showed the course of disease and the gestational age were significantly different (P<0.05);(2)No outcomes was reported in the first group. Increased rate of abortion and neonatal asphyxia were found in the third group than in second group. The mean neonatal birth weight and Apgar in unwell treated cases were significantly lower than that in the other two groups.(3) Pregnancy complications were significantly higher than that in the other two groups .Conclusion: Early detection and systematic pattern of treatment can significantly improve the prognosis of the maternal and fetus.