The Plasma Level Of Lp-pla2 And Mmp-9 In Acute Coronary Syndrome Patients And Its Clinical Significance

ObjectiveTo explore the stability value of plasma of lipoprotein-associated phospholipaseA2 (LP-PLA2) and Matrix Metalloproteinases-9(MMP-9) in predicting people sufferer acute coronary syndrome, as well as how the percutaneous transluminal coronary intervention (PCI) affecting the plasma level.MethodsResearch objects include comparison groups:proved by coronal artery angiography that no sufferring Coronary Artery Stenosis,28 cases; Acute Cornary Syndrome (ACS) sufferer,27 cases; stable angina pectoris (SAP) sufferer 28 cases. All research objects were collected blood samples when hospitalized, after heparin, we use centrifugal separater to separate the plasma, here we adopt the ELISA testing to collect plasma express level of LP-PLA2 and MMP-9, ACS sufferer under PCI for a month will collect blood sample again apart from the first time, after heparin, we use centrifugal separater to separate the plasma, here we adopt the ELISA testing to collect plasma express level of LP-PLA2 and MMP-9.Results1. The LP-PLA2 and MMP-9 of plasma level of ACS group is higher than SAP and health control group (706.00±149.91ng/ml vs 427.75±44.58ng/ml vs vs 267.69±92.67ng/ml, all P<0.001) and (7.06±6.22ng/ml vs 1.84±0.46ng/ml vs 1.84±0.46ng/ml, all P<0.001);2. In ACS group, after the percutaneous transluminal coronary intervention for a month, the plasma level of LP-PLA2 and MMP-9 are significantly lower down than before(706.00±149.91ng/ml vs 520.00±30.36 ng/ml; 7.06±6.22ng/ml vs 2.52±1.54 ng/ml, all P<0.001).3. In ACS group, the plasma level of LP-PLA2 and MMP-9 present positive associations(r=0.018, F=6.032, P<0.05)Conculsion1. The plasma level of LP-PLA2 and MMP-9 in ACS group is uppered cues that LP-PLA2 and MMP-9 as inflammatory factors associate with ACS;2. In ACS group, the plasma level of LP-PLA2 and MMP-9 present positive associations, cues that LP-PLA2 and MMP-9 can be associated as the biomarker of ACS;3. In ACS group, after the percutaneous transluminal coronary intervention, the plasma level of LP-PLA2 and MMP-9 are lower down than before, cues that PCI makes coronary atherosclerosis lesion tend to stability.