Chemical Composition Of An Annona Endophyte F-31

Plant endophytic fungus is an important source of natural active compounds. An endophytic fungus F-31 (identified as Periconia sp.) derived from Annona muricata L which can inhibit proliferation of several tumor cells was selected for the chemical investigation.Six new compounds, (4S,5R,9S,11S,12S)-Periconone A (1), 7-Hydroxy-11β,12α-dimethyl-9,10-dihydronaphthalene-1,6-dione (2), (6S,9R,10R, 12R,16 R)-Periconone C (3), (-)-(1R,4S,6R,7R)-2-Caren-4,9-olide (4), (3S,6S, 7R,8S)-Periconone B (5),4-(3'-Hydroxybutyl)-4H-furan-l-one (11), along with five known compounds, Chloranthalactone E (6),5,7-Dimethyl-6-hydroxycoumarin (7), L-Tryptophan (8), 1,2,4-Triazole-(1'R,2'R,3'R,4'R)-nucleosides (9), L-Phenylalanine (10), were isolated from the ethyl-acetate extraction of broth and water-soluble fraction of mycelia by means of chromatographic techniques and identified by various spectroscopic methods.The in vitro pharmalogical evaluation results displayed that the above compounds exhibited no inhibitory effects on the proliferation of six tumor cell lines (HCT-8, Bel-7402, BGC-823, A549, A2780 and MCF-7).