| Objective:Through the endometriosis conservative postoperative patients were randomized to take series of Chinese medicine,such as guifuyin, danchiyin, or qidanyin and gonadotropins agonists (GnRH-a) drugs or gestrinone,to evaluate the relapse rate,pregnancy rate, adverse reaction rate and amenorrhea rate of the two interventions within 1 year after conservative surgery, And discussing the feasibility of preventing the recurrence after conservative surgery with Chinese medicine diagnosis and treatment in order to seeking for the best formulaes that are efficacy,stability,low recurrence rate and adverse reaction.Methods:To collect the integrity of the clinical data of 240 patients admitted each branch center diagnosed conservative pelvic endometriosis patients for the first time after laparotomy or laparoscopic by pathological from April 2008 to February 2010.They were randomly divided into the trial group and the control group, each 120 cases. Both groups were followed up 1 time within every three menstrual cycles during and after taking the medication (within every 3 months if the menstruation to be not rule or amenorrhoea),and all patients were followed up for 1 year. Two groups were compared with the recurrent, pregnancy,adverse reactions and amenorrhoea etc within the follow-up periods. If the clinical is judgmented as pregnancy or recurrence, the research is terminated. The specific situation of the patients from April 2008 to February 2010 is completed research by earlier researchers.Results:This study takes 209 cases as research objects who complete treatment duration and were followed up to 1 year, and the observation group is 105 cases and control is 104 cases among them.1 year recurrence rate of two groups after conservative surgery:the observation group is for 7.6%, and the control group for 12.5%,so it was not statistically significant difference (P>0.05); the comparison of the recurrence rate about different operative methods in the observation group:for laparoscopic,it's for 7.3%, and for sigmoidectomy technique, it's 11.1%, so it was not statistically significant difference (P>0.05); the comparison of the recurrence rate about different stages in the observation group:forⅠ,Ⅱperiod,it's for 7.9%, and forⅢ,Ⅳperiod, it's 7.1%, so it was not statistically significant difference (P>0.05); the comparison of the recurrence rate about different operative methods in the two groups:for laparoscopic.it's for 9.7%, and for sigmoidectomy technique, it's 13.0%, so it was not statistically significant difference (P>0.05); the comparison of the recurrence rate about different stages in the observation group:forⅠ,Ⅱperiod,it's for 7.8%, and forⅢ, IV period, it's 12.9%, so it was not statistically significant difference (P>0.05); the comparison of the recurrence rate about the two groups accompanied by coincidence sac in preoperative:the observation group is for 6.9%, and the control group for 11.3%,so it was not statistically significant difference (P>0.05); the comparison of the recurrence rate about the two groups accompanied by coincidence dysmenorrhea in preoperative:the observation group is for 6.7%, and the control group for 11.3%,so it was not statistically significant difference (P>0.05); 1 year pregnancy rate of two groups after conservative surgery:the observation group is 26.7%,The control group is for 23.4%,it was not statistically significant difference (P>0.05); the comparison of the pregnancy rate about different operative methods in the observation group:for laparoscopic,it's for 28.1%, and for sigmoidectomy technique, it's 11.1%, so it was not statistically significant difference (P>0.05); the comparison of the pregnancy rate about different stages in the observation group:forⅠ,Ⅱperiod,it's for 33.3%, and forⅢ,Ⅳperiod, it's 16.7%, so it was not statistically significant difference (P>0.05); the comparison of the pregnancy rate about different operative methods in the two groups:for laparoscopic,it's for 24.7%, and for sigmoidectomy technique, it's 4.3%, so it was statistically significant difference (P<0.05); the comparison of the pregnancy rate about different stages in the observation group:for I,11 period,it's for 28.4%, and forⅢ,Ⅳperiod, it's 15.1%, so it was statistically significant difference (P<0.05); the comparison of the pregnancy rate about the two groups accompanied by coincidence infertility in preoperative:the observation group is for 66.7%, and the control group for 25.0%,so it has statistically significant difference (P<0.05);the adverse reaction rate (10.5%),adverse reaction degree and amenorrhoea rate of the observation group is obviously lower than the control, so it has statistically significant difference (P<0.01).Conclusion:By jointing herbal treatment endometriosis after the EMs conservative postoperative,the curative effect is stable,and side effect was small.It can decrease the recurrence rate,increase pregnancy rate.So it is worthing clinical promotion。... |
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