Warming Kidney And Spleen And Treatment Of Diarrhea-predominant Irritable Bowel Syndrome Clinical Observation

Irritable bowel syndrome is a functional disease which is not a threat to the life, but its long course and relapse have influence on the work and life of people and results in the huge waste in medical and health resources. So IBS has aroused the attention of international medical community. The traditional Chinese Medicine raise the cure rate and reduce recurs in TCM syndrome differentiation, and the TCM gradually has superiority in IBS.Literature Review:This part outlined the recent progresses in the TCM and western medicine researches on IBS-D. First, it introduces the western medicine progresses in epidemiology, pathogenesis, clinical diagnostic standard and various treatments. And meanwhile it introduces the TCM understanding to the disease name, etiology, and pathogenesis of IBS, and the progresses in syndrome differentiation, all kinds of treatments in herbal medicine, acupuncture, Tui Na massage, and integrated Chinese and western medicine and analyses the curative effect of these treatments. Through summarizing these documents, the literature review says the existing problems and research foreground of IBS-D. Above all, these theories provide basis for the TCM research in IBS-D.Clinic Study:Objective:To explore the therapeutic effect and mechanism of Wen Shen Jian Pi Soup in treating Spleen Yang-deficiency and Kidney Yang-deficiency syndrome of irritable bowel syndrome-diarrhea (IBS-D) and show the safety of Wen Shen Jian Pi Soup.Methods:This research was based on 82 cases of outpatients from Beijing Xuanwu Traditional Chinese Medicine Hospital during March 2009-February 2011 who meet Rome III diagnostic criteria and Spleen Yang-deficiency and Kidney Yang-deficiency syndrome of TCM. They wererandomly divided into two groups.1 case of each group is lost. One group is the treatment group,40 patients of which were treated with Wen Shen Jian Pi Soup, Shuijianbi,150ml, three times a day. The other group is the control group, with 40 patients being treated with placebos, Shuijianbi,150ml, three times a day. The cases of both groups are treated 4 weeks and followed up 1 month. There was no statistical difference between two groups in age, sex, course, IBS-SSS severity scores and scores of traditional Chinese medical symptoms (P>0.05).Results:In the treatment group(40 cases),14 cases recovered and 16 cases significantly improved,7 cases improved. The total effective rate in the treatment group is 92.5%. In the control group(40 cases),2 cases recovered, 5 cases significantly improved and 10 cases improved. The total effective rate in the control group is 42.5%. There was statistically significant difference in the total effective rate between the treatment group and control guoup (P<0.0001). There is statistically significant difference in IBS-SSS severity scores and single score of IBS-SSS between the treatment group and control guoup (P<0.0001). There is statistically significant difference in total and single scores of traditional Chinese medical symptoms between the treatment group and control guoup. For the recurrent, the treatment group is 8.33% The control guoup is 33.33%. But, there is no statistically difference in the recurrent between the treatment group and control guoup (P<0.05).There is no statistically difference in safty indicators such as WBC, RBC, Hb, PLT, ALT, AST, BUN, Cr, Glu and ESR between the treatment group and control guoup (P<0.05).Conclusions:1. Above all, Wen Shen Jian Pi Soup appears to have the significant effect in the treatment of Spleen Yang-deficiency and Kidney Yang-deficiency syndrome of IBS-D. It has improved the clinic syptoms, TCM syndrome and the quality of life of IBS-D patients.2. The trial shows the clinic safety of Wen Shen Jian Pi Soup.