Urine <sub> 1 Alpha </ Sub>-mg In Detection Of Cisplatin Nephrotoxicity In Clinical Significance

Aims: l. To study whether the urinary a 1--microg1obulin(Q 1--MG) is a sensitive and re1iab1e indicatorfor the renal damage of combining cisplatin-based chemotherapy.2. To investigate the nephrotoxicity of chemothe-rapy with different dose cisplatin.3. To research the factors of effecting theurinary a 1--MG stabi1 ity.Methods t 1. The factors of effecting the urinary a 1--MGstabi l ity: the temperature for urinarystorage (nomal temperature. 4OC' --20"C), thetime for urinary storage (1 week. 2 weeks) lcomparing the va1ue of random urinary Q 1-MG/Cr with the concentration of randomurinary a 1--MG, which is the more stable.2, The urinary a 1--MG was assayed both inhea1thy group, and in tumor group and nodifferent between the two groups.3. 45 cases of tumor patients were divided.into three groups: A group (noma1 dose); Bgroup (high dose cisplatin by used twice),C group (high dose cisp1atin by used once).the urinary samp1e before and after chem-otherapy one day, two days, three days, fivedays, seven days, ten days, 14 days weretaken in the ear1y morning, and stored in4OC, all the samp1es were measured with RIAwithin one week. the p1asma BUN and Cr wereassayed at the same time and to study a11of these indicators have any change after. - -c l sp1at in chemotherapy.Resu Its t 1. The urinary a,--MG 1ost 1ower when urine is,stored in 4oC and assayed within one week.2. The va1ue of urinary a,--MG/Cr is more tab1ethan the concentration of random urinaryQ 1---MG.3. The urinary a,--MG had no difference betweenthe tumor and the hea1thy groups p>0. 05) the,value of the urinary a,--MG/Cr after chemot-herapy the different dose cisp1atin groups.1t needs 7--10 days for high--dose to recov--er rena1 damage. Whi 1e the p1asma BUN. Crhad no statistic difference after chemoth-erapy (p>0. 05).Gonc l us ions t 1. The urinary Q,--MG is a sensitive and-re1iab1e indicator for rena1 damage ofcombining cisp1atin--based chemotherapy.2. It is about 7--10 days for nephroto-. lxlcity of the combining cisp1atinbas-ed chemotherapy to recover in the 60--90mg/m'.3. The urinary a,--MG lost 1owest whenthe urine is stored under 4oC and,assayed within one week and the va1ueof urinary a,--MG/Cr is more stab1ethan the concentration of randomurinary a,--MG.