Obese Patients Serum Igf-1, Igfbp-1 And Igfbp-3 Levels And Metabolic Factors In The Relationship Between

Background: The amounts of the obese persons are increasing recently in the world, and which is noticed by researcher. Recent studies suggest a role for GH and IGF-1 in the pathomechanism of obesity. It is well established that spontaneous and stimulated growth hormone (GH) secretion is diminished in human obesity, and may be regulated by IGF- 1. IGF-1 is not only endowed with negative feedback effect to GH, but lipid metabolic regulation itself However,the evaluation of total IGF-I serum levels in obese patients has yielded conflicting results. Normal, low or high serum concentrations of IGF-1 have been described. It is suggested that the low levels of total IGF-1 is not associated with reduced somatic growth. Recently it has been suggested that the obesity-related hyperinsulinemia may increase free (bioactive) IGF- 1 by reducing the concentrations of IGFBP-l. Objective: To compare serum free LGF-1,IGFBP-1,IGFBP-3 concentrations in obese and normal subjects, and evaluate their possible relationships to age, body mass, fat distribution, metabolic and hormonal 4 variable in obese patients. Subjects and Methods: 97 obese outpatients (57 female and 40 male, age 18-71, BMI>25kg/m2) and 84 healthy subjects (38 female and 46 male, age 18.5