With Obstructive Sleep Apnea Syndrome In Patients With Autonomic Nervous System Function

Objective The Study was to investigate nocturnal variation of autonomic nervous system (ANS) in patients with obstructive sleep apnea syndrome (OSAS).Heart rate variability(HRV) can provide information of sympathetic and vagus activties.Methods 66 subjects with OSAS were recruited to undergo 7-hour nocturnal polysomnography(PSG)in sleep lab.16 subjects with OSAS were undergo PSG before and after UPPP. 16 subjects without OSAS were included as controls.Result The mean areas of LF[(1108.23±87.22):(530.94±227.48)], HF [(689.38±535.89):(411.38±212.89)] and LF/HF[ (2.21±1.28):(1.35±0.55)] in OSAS subjects were significantly higher than those in the controls(P<0.05). with UPPP treatment, LF[(1307.61±181.99):(770.41±160.18)], HF [(811.81±212.44):(450.44±140.10)] and LF/HF[(2.69±0.43):(1.38±0.096)]decreased significantly(P<0.05).The number of ventricular or supraventricular premature beats and blood pressure in OSAS subjects increased remarkably(P<0.05), especially in the sleep stage REM . AHI,HR and BP were significantly correlation with ANS. Conclusion The results suggested that nocturnal of ANS activities are abnormal in patients with OSAS, especially the enhancement of sympathetic nervous activity . The increased sympathetic activation that occurs in OSAS may play an important role in associated cardiovascular diseases. Treatment of OSAS by UPPP significantly reduced the parameters of ANS.