Harmonic Power Doppler Tissue Imaging With Myocardial Imaging Evaluation Of Acute Myocardial Infarction, Reperfusion Injury And Its Pathological Basis Of The Experimental Study

Background. With the quick development of new ultrasonic techniques and ultrasonic contrast agent, myocardial contrast cchocardiography(MCIZ) is entering clinicil practice . The development of clinical internal medicine, surgery and interventional medicine can give immediate treatment to those who are suffering from coronary heart disease and myocardial infarction . However, the isehemiaeperfusion injury after myocardial infarction may damage its clinical effect, and ord i nary coronary vaScular contrast by rad I ol ogy can?t provide us with picture arid observations ot coronary microvascular and its signs, so we can?t determine its clinical effect. Therefore, MCE is coming out and becoming popular in observing normal and abnormal cardiac perfusion. Objective. To ol)serve normal perfusion and ischemiaeperfusion , study MCE evaluation value for cardiac perfusion, damages after ischemiaeperfusion and damages from endotheliumependent vascular relaxation function(EDVR[) and nonndotheliumependent vascular relaxation function(NEDVRE), and its pathological basis. Materials and Methods. Twelve dogs underwent 2 hours of left anterior descending( LAD) coronary occlusion, followed by 40 minutes reperfusion . Pixel video intensity (PVi) was measured at baseline and at 5, 10, 15, 30, 35 mm during reperfusion. At the same time points, MCE was performed with intravenous infusion of perfluorocarbon gas (CF,) contrast agent by using Doppler tissue energy imaging(DTIS), second harmonic imaging (SIlI),and intermittent ultrasound imaging (IUI). At baseline and at each time points, acetylcholin (ACH) and nitroglycerin (NG) was injected in aortic root . the l~V1 value of after and before using drugs was computed as well as their ratio value, which could represent the EDVRF and NEDVRF of myocardial microvascular. Results. First, the PVI of normal cardiac muscle and myocardial contrast of each regional left ventricular walls was anisotropic, and significant different (P < 0.001 Second, the difference of PV1 after and before myocardial contrast of each regional left ventricular walls was also anisotropic . There has significant difference (P