The Dissolution Of The Multi-channel Fiber Optic Sensing Monitor The Development And Application Of Technology

Study on the multichannal fiber-optic sensors applied to process monitoring for the drugs dissolution Abstract Dissolution test denotes the absorb degree of druggery and bioactivity,which is one of the important guideline to estimate the prescribe and manufacture technic. With the rapid development of the sensor and micro electronic technic, the analysis of pharmaceutic dissolutions as same as other subjects enter the period of the automatization and intelligentize,which signification not only instead of the heavy handwork, but also maxium reduce the artificial interfere,improve accuracy and reproducibility of the analyse method. Fiber-Optical chemical Sensor(FOCS) is a new technology,which break through conventional pattetn,light straight guided by fiber optic, you can detect the sample directly without sampling.The technic can actual reflect the change of various signal in time,which is usually applied in pharmacy,environment contamination and monitoring in production.This paper included two parts,the first part research a multichannal instrument based on the technic of FOCSMQ.The instrument can monitoring the dissolution of the solid druggery on-line in 6 different point at the same time.the second part apply the instrument to monitor two sorts of medicine. The instrument made up of hardware and software.Hardware include xenon light,multichannal fiber optic chemical sensor and multichannal detector system. The instrument use one photomultiplier detect and record data with 6 different signals by controling accurately 5 step motor. In additional,the instrment build-in data process software, programmed by visiual basic 6.0,which adopt modularize programmes.which according to the value of r to choose the best from 5 maths models,and calculate the parameter of the pharmacy dynamics.For ofloxacin tables,the mean recovery(%) of method was 101.1?.4%, the precision(CV%) of within-day and day to day were less than 5%.the results of measurement using instrument have no significant difference compared with Ch.P.(2000) method. For Metronidazole tables,the mean recovery(%) of method was 101.1? 4.4%, the precision(CV%) of within-day and day to day were less than 5%.the results of measurement using instrument have no significant difference compared with Ch.P.(2000) method. All tests proved the multichannal fiber chemical sensor instrument linked with computer can be applied to practical.