Experimental Study Of The Shenshuning Treatment Of Rat Mesangial Proliferative Glomerulonephritis

ShenShuNing(SSN) is a representative prescription that embodies professor Huang抯 guiding thought of regulating Qi of shaoyang by alleviation of depression, invigorating Qi and nourishing Yin, activating blood circulation, clean away heat and promoting diuresis and removing toxic substances when treating Mesangial proliferative glomerulonephri tis in the expreirnent, to make the rat model of MsPGN by feeding bovine serum albumin (2mg/d), injecting Freunds adjuvant (2m1/kg) periodical (7th amd 14th day) and treated with SSN, at the same time, use SheYanKangFuPian(SYKFP) as control. To observe the changes of 24h protein, plasma protein, renal function and the content of NO, NOS. The experimental results show that SSN can obviously reduce MsPGN rat抯 urinaly protein, improve plasma protein, enhance renal function and the content of NO, NOS in the kidney tissue.This syudy has further verified the curative effect and discussed the functional mechanism of SSN thus providing objective basis for its clinical application.