(188) Of Re (~ (153) Sm)-hedtmp In The Ha Adsorption Study

The investigation of complex adsorption on hydroxyapatite(HA) which is used as a skeleton model may forecast the capability of complex adsorbing on bone. HEDTMP is synthesized newly and testified capable to adsorb on bone. The investigation of 188Re-HEDTMP and 153Sm-HEDTMP adsorbing on HA will estimate well their capability adsorbing on bone.HA particle with various diameter prepared by precipitation reaction and nanograde HA prepared by sol-gel process are analyzed by XRD and IR measurement and the analysis results show that the productions are what we want. The particle diameter of the nanograde HA ranges between 10 and 50 nanometers according to TEM analysis.The adsorption rules of 188Re- HEDTMP on HA are investigated. The results show that the adsorption balance is reached in 15 minutes and little influenced by temperature. The competing adsorption of HEDTMP to the complex leads to remarkable reduce of the adsorption yield of 188Re- HEDTMP on HA. The high acidity benefits to increase the amount of adsorbed complex. The adsorption of excess ligand and its complex with Sn competes so strongly with 188Re- HEDTMP that the amount of quantitative adsorption of 188Re- HEDTMP on HA is only 2.0 umol ?(gHA)"1. The uptake increases in certain extent with the addition of Ca2+ ions. Because they can be absorbed on HA, HEDTMP and EDTMP desorb remarkably the adsorbed complex largely. The adsorption yield of I88Re- HEDTMP on HA increases when the particle size of HA decreases, but it is not proportional to. The trend of adsorption curves of the complex on nanograde HA and commercial HA is similar but the quantitative adsorption amount of the former is higher than that of the latter. The adsorption amount on collagen is 6.0umol - (gHA)-1 and it is three times more than that on HA. The adsorption curve of Sn4+ is linear in a wide range and its HEDTMP complex has an adsorption amount of 55umol ?(gHA)-1 which is 27 times more than the amount of 188Re- HEDTMP. The stability of the adsorbed complex on HA is tested and the results show that the stability is better under the high acidity but worse when diluted and oxidized.The adsorption rules of 153Sm-HEDTMP on HA are investigated. The results show that the adsorption balance is reached about 20 minutes and little influenced by temperature. The competing adsorption between excess ligand and the complex leads to reducing the adsorption of 153Sm-HEDTMP on HA. The adsorption yield is higher in the range of lower pH value. For Sm3+, the quantitative adsorption amount isup to 720 umol - (gHA)-1. While the amount of quantitative adsorption of 153Sm-HEDTMP on HA is 61 umol (gHA)-1, more than that of 153Sm-EDTMP, which is attributed to the hydroxyl in HEDTMP forming hydrogen bond with the PO43- on the surface of HA. The addition of Ca2+ ions intensively promotes the adsorption of the complex on HA. HEDTMP and EDTMP can desorb the adsorbed complex largely but physiological saline desorbs barely. When the particle size of HA decreases the adsorption yield of 153Sm- HEDTMP on HA increases. The trend of adsorption curves of the complex on routine HA and nanograde HA is similar though the amount of quantitative adsorption of nanograde HA is more than that of commercial HA. When pH ranges from 4 to 9 or the adsorbing system is diluted, the absorbed complex on HA shows high stability.