Rat Eeg Analysis To Deal With Sleep Stages

A good physiological sleep has the function of restoring physical energy and brain energy in human being. However, a sleep evoked by hypnotic (the drug sleep) always has some side effects, such as aggravating the feeling of daze and weariness that caused by insomnia even after the drug sleep. So, if we can bring to light the differences between the physiological sleep and the drug sleep using pharmacological methods, it will be helpful to the development of new safer hypnotic with few side effects.By recording the cortical EEC and the hippocampal EEC in freely moving rats, we developed some methods to analyze the properties in the rat sleeps under different conditions using the technology of chronic electrode implanting and the technology of computer signal processing, ffe developed lots of analysis methods such as the Time-Frequency domain, AR PSD, Wigner-Ville distribution, wavelet transform and non-linear analysis. Gravity frequency(fg) and the complexities measures were calculated. The fg and complexities of Kc, C,, Apen can be used not only to distinguish the difference between cortical EEC and hippocampal potential, but also to reveal characteristics between the same kind of potentials under different behavioral states. According to the characteristics of each stage and by studying the histogram of fg, Kc , C, and Apen, the stages of rat sleep were distinguished. Comparing the results of visual and our analysis, the rate of accordance is above 80%, and the analysis based on the complexity measure is more believable than that based on the fg.In a conclusion, we provide a new reliable and efficient tool for quantitatively ananlyzing rat sleep, and will be further improved in order to assess the effects of sedative or hypnotic medicine on sleep.