The Synthesis Of Pyrrolidine Hydrochloride And Quinoline Compounds And Anti-inflammatory Analgesic Effect

The synthesis and structure-activity relationship (SAR) of tetrahydro-pyrrolizino[2,1-c]quinolines are reported in this paper.The interest of the study of the SAR of 2-(4-methylphenylamino)-methyl-l,2-dihydro-1-pyrrolizinones led the synthesis of novel tetracyclic compound, 1,2,6b,11a-tetrahydropyrrolizino[2,1-c]quinoline. Fifteen new compounds of the kind were designed and synthesized, and the structures were evaluated.Pharmacological studies show that most of the compounds have significant analgesic activity on mice. The analgesic activity of Compound ZL-403, ZL-406 are comparable to ibuprofen.Some SAR of analgesic activity was summarized.