| Objective: To evaluate the effect of valsartan on cardiac function and vegetative nerve function in patients with essential hypertension . In another word, the aim is to evaluate its protection of heart and regulative effect on vegetative nerve. Methods: 31 Patients with essential hypertension were selected(1st grade group with 8 patients,2nd grade group with 18 patients and 3rd grade group with 5 patients)and treated with valsartan 80mg/d for eight weeks. Before treatment and after eight weeks treatment, the cardiac function and vegetative nerve function were measured .In the same time, the blood pressure was detected everyday. Recording the blood pressure of the third day,the 1st week ,the 2nd week ,the 3rd week,the 4th week ,the 6th week and 8th week after treatment.And observing heart rate,the incidence of dry cough and clinical laboratory measurements. If necessary ,hydrochlorothiazide(12.5mg/d)was added after 3 days or 2weeks. Results: After 8 weeks treatment, LVET,PEP,PEP/LVET,EF,ICT,Hle,Hsd,Hcc and RUH were significant improved (p＜0.05).The total efficiency rate and obvious rate were :the 3rd day(26% and 3%),the 1st week(74% and 16%),the 2nd week(84% and 68%),the 3rd week(87% and 81%),the 4th week(87% and 77%),the 6th week(94% and 84%),the 8th week(94% and 84%).There was no significant difference in clinic laboratory measurements. Conclusion: The cardiac function and HRV in patients with essential hypertension treated with valsartan were significant improved.The effect of decompression was obvious. |
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