Multi - Metals And Oxygen Acid Salts Containing Drugs Active Substances I Amantadine Metal Oxygen Acid Synthesis, Crystal Structure And Antibacterial And Antiviral Activity

In order to research the medical activities of heteropolyoxometalates, 15 new heteropolyoxometalates containing amantadine, in 5 structural series (Keggin, Dawson, Anderson, nickel-13-vanadate and lanthanide-10-tungstate) were synthesized and structural characterized. Three crystal structures were obtained:(C₁₀H₁₈N)₅PMo₁₂O₄₀Cl₂·5H₂O,nomoclinic,P2₁／n,a=14．434(3)(?),b=26．258(5) (?),c=23．438(5) (?),α=90°,β=93．72(3)°,γ=90°,V=8865(3)(?)³,F(000)=5392； (C₁₀H₁₈N) ₄SiMo₁₂O₄₀·6CH3CN·6H₂O,nomoclinic,P2₁／c,a=20．558(5)(?),b=12．857(6)(?),c=28．425 (?),a=90°,p=90．073(8)°,γ=90°,V=7513．67(?)³,F(000)=5084； (C₁₀H₁₈N)₆ As₂Mo₁₈O-(62)·6CH₃CN·6H₂O,nomoclinic,C2／c,a=16．104(5)(?),b=23．055(5)(?),c=33．753(13)(?),α=90°,β=96．30(3)°,γ=90°,V=12457 (7)(?)³,F(000)=8160． The antibacterial and antiviral activities of these new compounds were measured, and some compounds exhibited inhibition to both bacteria and viral.The mechanism of hydrolysis of N, N-dimethylformamide catalyzed by Keggin type heteropolyacid was researched and the crystal structure of the hydrolytic product [(CH3)2NH2]3PMo12O40 was obtained: Trigonal, R3, a=16．5412(?),b=16．5412(?),c=25．154(?),α=90°,β=90°,γ=120°,V=5960(?)³,F(000)=5520．...