Clinical Studies Of Drug-resistant Strains Of Neurosurgery

OBJECTIVE　To explore the characters of infection caused by extended-spectrum-β-lactamases-producing (ESBL-producing) bacteria in neurosurgery department and provide bases for selecting rational antibiotics in clinical practices.METHODS　318 strains of organisms isolated from neurosurgery department from July 1999 to July 2002 were detected for ESBL by the performance standards recommended by NCCLS (National Committee for Clinical Laboratory Standards) and the clinical data from the relevant cases was reviewed. RESULTS 36 strains of ELBL-producing organisms , accounting for 11.3% of all the strains detected, were isolated. The infections of ESBL-producing bacteria occurred in 27 cases in respiratory tract and 9cases in urinary system. The average period of administering ceftizime was 13.3 days and the average hospitalization time 40.3 days. CONCLUSIONS The long-term and large-dosage use of the third generation Cephalosporines is one of the most important factors of inducing ESBL. Avoiding irrational use of the third generation Cephalosporines and enhancing the recovery of cerebral function with improvement of nutrition are the basic ways to reduce the infections from ESBL-producing organisms.