Spleen Diarrhea Particle Treatment Of Children With Diarrheal Disease Clinical And Mechanistic Studies

Infantile diarrhea is not only one of the important diseases of the digestive system, also main prevention and cure disease of our country. WHO ranked diarrhea control as national stratagem, in developing countries, diarrhea still is the main reason of children death. TCM cognition to the disease is old-line, seasoned and curative effect affirmed. But the majority deem that the reasons of diarrhea are climatic factors in excess, irregular diet, insufficiency of spleen and stomach, accumulation of dampness-heat. In clinic, the cure of types based on syndrome differentiation is often adopted. By famous -old TCM professor WangPengfei's practical recipe this research put 260 diarrhea infants in clinical practice, discussed this practical recipe in mechanism, established foundation for researching more about infantile diarrhea, provided preparative for researching more about this Chinese herb medicine and making for market.The essay includes literature outline, clinical research, mechanism canvass.Literature outline: Discussed ancient TCM' s cognition to pediatric diarrhea's definition, etiology, pathology, treatment and the principle of treatment determination based on syndrome differentiation, and summarized TCM' s diagnosis and treatment of this disease in resent 10 years', discussed from treatment determination based on syndrome differentiation and opened out the present research actuality to the disease and the deficiency.Clinical study: 260 cases, which accord with condition, were divided randomly into two groups - treated group (200 cases) and control group (60 cases), and recorded the clinical information about the infant respective and gave different treatment according to group. Period of treatment was 5 days. The conclusion were obtained by statistical data.1. The recipe had definite curative effect to diversified diarrhea, especially to chronic diarrhea, deficiency of spleen diarrhea.2. "Invigorating the spleen to curing diarrhea granule" could resist infect definitely, especially to enteropathogenic E. coli, enterococcus, strange anamorphic bacteria,control and sterilization effect are more definite.3. The rate about infective factor in infantile diarrhea was researched relatively. It explained that the rate about infective diarrhea in infantile diarrhea wasn't high, thereby more validated the irreasonability of bacteriophage's abuse in present clinic.4. The difference of urine D- xylose mensurations of fore-and-aft treatment to part of chronic diarrhea infants wasn't obvious, perhaps this phenomena was relate to short period of treatment and absorptive function of small intestine.Mechanism study: The mechanism study was taked by BeiJing TCM university, which as the cooperative unit, "invigorating the spleen to curing diarrhea granule", which included main effect of medicine test, emergency toxicity test, least control bacteria concentration test, etc.1. Main effect of medicine test: Invigorating the spleen to curing diarrhea granule had no effect to well-balanced stomach excretion, but could control the speed of small intestine impelling, could control the speed of sthenic small intestine impelling caused by neostigmine, had counteractive to diarrhea caused by cassia acutifolia delile.2. Emergency toxicity test: The biggest dose was 180g/kg/d, in the process of test, emergency toxicity test didn't find.3. Least control bacteria test: the smallest sterilization concentration of invigorating the spleen to curing diarrhea granule to enteropathogetic E. coli was 0.0625g/ml.