Intensive Insulin Therapy On Blood Glucose And Inflammatory Factors

Objective: l)To estimate the implication of Continuous Glucose Monitoring System continue (CGMS) in diabetic patients with intensive insulin therapy; 2)To investigate the effecs of intensive insulin therapy on the inflammatory factors in newly onset diabetics; 3) To study the efficacy and safety profiles of lispro on patients with diabetes. Methods: 1) CGMS and periphery capillary blood monitoring were used to detect the blood glucose levels in patients with diabetes on continuous subcutaneous insulin infusion(CSII); 2)38 Newly diagnosed diabetic patients were divided into multiple daily insulin injection group (MDI) and CSII group. All patients were treated with insulin for one month, serum C-reactive protein(CRP) and intercellular adhesion molecule-1(ICAM-1) were measured using euzymelinkedimmunosorbent assay (ELISA) before and after insulin treatment; 3 ) Diabetic patients who were treated with regular insulin routinely were switched to insulin lispro or Humalog for three months. Dosages were adjusted depending on blood glucose levels. Glycosylated hemoglobin and blood glucose were measured before and after insulin treatment. Results: 1 ) There were statistical difference of the highest and lowest of blood glucose levels between CGMS and periphery capillary blood monitoring group. The hypoglycemia rate detected with CGMS was higher than that of periphery capillary blood monitoring group periphery...