| Background and Oberjective: Alzheimer's disease (AD) is a primary neurodegenerative disease with the clinical manifestation of progressive impairment of memory cognition, disorder of mind and behavior, and even the incapability of daily life. This study was designed to investigate whether there are influence on the behavior and memory skills of rats which were injected Resveratrol after they had been injected D(+)galactose.Methods: sixty rats were randomly divided into 3 groups according to the injection (normal saline, D(+)galactose Resveratrol). Every group has 20 rats. The D(+)galactose group and the Resveratrol group had been continually injected D(+)galactose for 72 days. And the Resveratrol group had been continually injected Resveratrol from the 22th day to the seventy-second day. After these animal models were finished they were undergo these tests including Step down test, Y type maze Step through test, Morris maze test and Lipofuscin quantitative analysis.Results: such variation of swimming length and the numbers through the flat roof in morris maze test and the right numbers in Y type maze Step through test and the brain lipofuscin content were statistically valid by SPSS analysis between the D(+)galactose group and the Resveratrol group (P<0.05) .but there are no statistical variation in the flat step about the numbers of errors.Conclusion: Resveratrol can improve the behavior function and memory skills of the rats which were injected D (+) galactose. Resveratol can inhabit the development... |
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