Yuchangning Oral Colon Targeted Formulations Of Pharmaceutical Research

In recent years, the ulcerous colonitis(UC) incidence rises continuously,which draws more attentions from medicine vocation.Compared with western medicine,Chinese medicine has better curative effects and less adverse reactions, but the laggard dosage forms restrict its function.Thus the research on oral target preparations for colonitis in TCM is very important and urgent.According to documents and pharmacological trials, the innovative compounded Chinese medication Yuchangning for UC was sifted systematically.The prescription is composed of astrageloside,amylase,ma-trine,oxymatrine. Established internal standards for astrageloside and amylose extractions that have no national standards.At those effective components above,developed reaserches on the molding technics of PH depended type colon target preparations of Yuchangning and PH depended-time lagged type ones.As to patent drug,established a TLC method for identifying astragaloside , matrine and oxymatrine as well as a HPLC method for determination of matrine and oxymatrine, formulated the content limits of matrine and oxymatrine in preparations.Regarding the accumulative dissolution percentage of matrine and oxymatrine as assessing indexes, established a method of in vitro dissolution determination for preparations.Besides,investigated some factors such as rev of PH value of solvents and tablets'hydrosopic...