Mechanisms Of Brain Function Of Schizophrenia Auditory Hallucinations

Objects1. To assess the differences of brain functions between schizophrenic patients with the symptom of auditory verbal hallucinations (AVHs) and without subgroups and normal health group by using neuropsychological tests.2. To investigate whether clinical symptoms were associated with neuropsychological measures assessed by schizophrenia patients with auditory verbal hallucinations (AVHs).3. To examine whether differ in the brain asymmetry amongst the the patients subgroups (with and without AVHs) and normal subjects. MethodsA total of 26 Chinese Han male patients with paranoid schizophrenia (SCH) and 13 matched normal control subjects were recruited for the present study. Schizophrenia was be diagnosed according to CCMD-3. Thirteen patients had AVHs, with a score of >4 for auditory hallucinations on the Scale for Assessment of Positive Symptoms (SAPS), and the other thirteen patients had no history of AVHs. All subjects were completely righted-handed and had no history of neurological system diseases, other mental disorders, several organic diseases, and drug or alcohol abuse. After complete description of the study to the subjects, written informed consent was obtained. All of subjects were assessed by auditory attention test (AAT), rhythm scale (RS), and verbal fluency test (VFT). Functional data were acquired using a 1.5 T GE system (GE Systems, USA), and were analyzed using statistical parametric mapping 2 (SPM2). A fixed-effects model was employed to assess the difference in BOLD response between "left-sided" and "right-sided" voices conditions. Results1 .Neuropsychological assessment (1) Pre-treatment...