3 - Thiophene Methoxy Acetic Acid And Its Derivatives Synthesis

Mingzhu Li etc discovers that ethyl 2-(benzyloxy)acelate has the very strong funetion that small rats study and memory something. Ethyl 2-(benzyloxy)acetate has the plant growth hormone function. Meclofnfenoxate Hydrochloride is the central nervous systim stimulant medicine to used for the clinic, waiting the nation to then be the improvement an application of the brain metabolism in Japan.It can clear brown (?) of fat in the cell. So we once synthesize 2-(dimethylamino)ethyl2-(naphth(?)xy)(?)eand2-(dimethylamino)ethyl2-(quinolin-3-ylmethoxy)acetate and didthe (?)ogous pharmacology experiment.As a result express that Meclofnfenoxate Hydrochloride still can promote the small rats 'studying and memorying,when the structure has changed.We synthesized ethyl 2-(thiophen-3-ylmethoxy)acetate and it's derivatives to find the small rat's studying and memorying promote function, plant growth hormone function, and did the homologous pharmacology experiment.The experiment result enunciation,it improvement the small rat ' s studying and memorying .The sample can resist the memory that ether cause to reappear theAccording to this originally ,the thesis carries one the work as follows: (1) Was respond by whol-zieler to get (2).(2)and sodium 2-elhoxy-2-oxo -efnanolate r(?)nd to (3).Compound 3 water solutions,sour turn to get(4)1. The reaction of the chlorineCompound 4 and sulfuryl dichloride respond to chlorine.It fuction diethyamine to N,N-diethyl-2-(thiophen-3-ylmethoxy)acetamide.It fuction aniline to N-phenyl-2-(thiophen-3-ylmethoxy)acetamide.It fuction p-toluidine to 2-(thiophen-3-ylmethox y)-X-p-tolylacetamid.It fuction piperidine to 1-(piperidin-1-yl)-2-(thiophen-3-ylmet hoxy)ethanone.Itfuction morpholine to 1-morpholino-2-(thiophen-3-ylmethoxy)etha none.It fuction hydrazine to 2-(thiophen-3-ylmethoxy)acetohydrazide.It fuction ((?)-trioxazetidin-4-yl)benzenamine to -nitrothenyl)-2-(thiophen-3-ylme-thoxy)acetami de.2. The derivatives of the esterCompound 3 and (dimethylamino)methanol synthesize to 2-(dimethyl-...