Triamcinolone Acetonide Nasal Spray

Seasonal and perennial allergic rhinitis comes on commonly and frequently, with a great morbidity among the population—about 5 to 20 percents. Triamcinolone acetonide is the preferred medicine for this disease .Nasal administration is an effective drug delivery route to treat allergic rhinitis. For these reasons, the author developed the preparation of triamcinolone acetonide nasal spray.The particle size was one of important factors affecting drug absorption. Taking nasal mucosa of rabbits as the diffuse barrier membrane , the author investigated the difference of penetrability in vitro between original drug material and micronized ones. After micronization, the steady state flux of drug was improved from 62.5μg·cm^-2·h^-1A to 240.1μg·cm^-2·h^-1 with no change of lag time. The method of DSC was used to study the compatibility between drug and ingredients .The results indicate that Triainolone acetonide was compatible with sodium chloride, CMC-Na, Tween-80. So it was rational to chose these ingredients in this spray formulation.On the basis of preformulation work, an optimal prescription was verified by orthogonal design with reference of triamcinolone acetonide suspension injection. After stress testing, accelerated testing and long-term testing, the appearance, granularity, content and decomposition product of the preparation were examined .The results suggested that it had a good stability and no distinct change of indexes were found.The experiment object was elected as experimental allergic rhinitis guinea pig model and increasing airway resistance rat model. The secretion in nasal cavity , times of sneeze, times of scratching nose, histology of nose in guinea pig and nose airway resistance in rat were observed as index to investigate the effect of triamcinolone acetonide nasal spray on allergic rhinitis. Triamcinolone acetonide nasal spray (5.0mg/kg, 10.0mg/kg, 20mg/kg) can obviously improve various kinds of symptom of allergic rhinitis on experimental allergic rhinitis...