Quinazoline Receptor Tyrosine Kinase Small-molecule Inhibitors

The characteristics of quinazoline epidermal growth factor receptor(EGFR) inhibitors were briefly described in this paper, and the mechanism of receptor-tyrosine kinase inhibitor(RTKs) was also introduced. The synthesis of this kind of new compound was studied, and the synthetic route was redesigned and the method was modified. From the work, 25 new compounds were got. The total yield of GX-1 was 39.6%, which was synthesized from 3-methoxy-4-hydroxymethyl benzoate. The structure of all compounds were confirmed by MS and 'H-NMR.